Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

doi:10.1007/s13659-019-0197-y

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (2): 139-144.DOI: 10.1007/s13659-019-0197-y

• ORIGINAL ARTICLE • Previous Articles Next Articles

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Chang-An Geng^1,2, Meng-Hong Yan^1,2, Xue-Mei Zhang^1,2, Ji-Jun Chen^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Kunming 650201, Yunnan, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2018-11-26 Revised:2019-01-06 Online:2019-04-04 Published:2019-04-24
Contact: Ji-Jun Chen
Supported by:
This work was financially supported by the Program of Yunling Scholarship,the CAS "Light of West China" Program (Western Youth Scholars "A"),the Youth Innovation Promotion Association CAS (2013252),and the Applied Basic Research Programs of Yunnan Province (2017FB137).

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Chang-An Geng^1,2, Meng-Hong Yan^1,2, Xue-Mei Zhang^1,2, Ji-Jun Chen^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Kunming 650201, Yunnan, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Ji-Jun Chen
基金资助:
This work was financially supported by the Program of Yunling Scholarship,the CAS "Light of West China" Program (Western Youth Scholars "A"),the Youth Innovation Promotion Association CAS (2013252),and the Applied Basic Research Programs of Yunnan Province (2017FB137).

Abstract

Abstract: A new flavane,bropapyriferol (1),and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay.The structure of compound 1 was determined by extensive 1D and 2D NMR,[α]_D spectroscopic data and quantum computation.Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro.Especially,compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis(MIC=1.95 ppm) than the positive control,triclosan.

Key words: Bropapyriferol, Broussonetia papyrifera, Anti-oral microbial activity

摘要： A new flavane,bropapyriferol (1),and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay.The structure of compound 1 was determined by extensive 1D and 2D NMR,[α]_D spectroscopic data and quantum computation.Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro.Especially,compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis(MIC=1.95 ppm) than the positive control,triclosan.

关键词: Bropapyriferol, Broussonetia papyrifera, Anti-oral microbial activity

Chang-An Geng, Meng-Hong Yan, Xue-Mei Zhang, Ji-Jun Chen. Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay[J]. Natural Products and Bioprospecting, 2019, 9(2): 139-144.

Chang-An Geng, Meng-Hong Yan, Xue-Mei Zhang, Ji-Jun Chen. Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay[J]. 应用天然产物, 2019, 9(2): 139-144.

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Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

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