Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

doi:10.1007/s13659-025-00563-2

应用天然产物 ›› 2026, Vol. 16 ›› Issue (1): 10-10.DOI: 10.1007/s13659-025-00563-2

Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

Meng Ding, Yue-Han Wang, Chen-Hao Liu, Wang-Xiao Tan, Li-Ming Hu, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China

收稿日期:2025-07-20 出版日期:2026-02-14 发布日期:2026-03-25
通讯作者: Yong Jiang,E-mail:yongjiang@bjmu.edu.cn
基金资助:
This work was financially supported by National Natural Sciences Foundation of China (Nos. 82173949 and U23A20514), the Key Research and Development Project of Shandong Province (2021CXGC010507), and the China Postdoctoral Science Foundation (2023M730132).

Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

Meng Ding, Yue-Han Wang, Chen-Hao Liu, Wang-Xiao Tan, Li-Ming Hu, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China

Received:2025-07-20 Online:2026-02-14 Published:2026-03-25
Contact: Yong Jiang,E-mail:yongjiang@bjmu.edu.cn
Supported by:
This work was financially supported by National Natural Sciences Foundation of China (Nos. 82173949 and U23A20514), the Key Research and Development Project of Shandong Province (2021CXGC010507), and the China Postdoctoral Science Foundation (2023M730132).

摘要/Abstract

摘要： Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved through integrated spectroscopic analysis, quantum chemical calculations (NMR/ECD), and single-crystal X-ray diffraction. All isolates were evaluated for neuroprotective effects. Compounds 3, 9-11, 13, 17, and 18 showed significant protective effects against oxygen-glucose deprivation/reperfusion (OGD/R)-mediated nerve injury in PC12 cells at 10 μM, while compounds 3 and 19 exhibited potent anti-excitotoxicity activity in the L-glutamate-induced HT22 cells at 20 μM. Strikingly, triterpenoids 1, 2, and 11 displayed remarkable activity against RSL3-induced PC12 cell death with EC₅₀ values ranging from 1.16 to 1.74 μM. Compound 22 exhibited the most significant inhibitory activity among the isolates against nitric oxide (NO) release in lipopolysaccharide (LPS)-activated BV2 cells with an IC₅₀ value of 22.41 μM.

关键词: Aglaia odorata Lour., Diterpenoids, Triterpenoids, Anti-neuroinflammation, Anti-ferroptosis, Neuroprotective activity

Abstract: Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved through integrated spectroscopic analysis, quantum chemical calculations (NMR/ECD), and single-crystal X-ray diffraction. All isolates were evaluated for neuroprotective effects. Compounds 3, 9-11, 13, 17, and 18 showed significant protective effects against oxygen-glucose deprivation/reperfusion (OGD/R)-mediated nerve injury in PC12 cells at 10 μM, while compounds 3 and 19 exhibited potent anti-excitotoxicity activity in the L-glutamate-induced HT22 cells at 20 μM. Strikingly, triterpenoids 1, 2, and 11 displayed remarkable activity against RSL3-induced PC12 cell death with EC₅₀ values ranging from 1.16 to 1.74 μM. Compound 22 exhibited the most significant inhibitory activity among the isolates against nitric oxide (NO) release in lipopolysaccharide (LPS)-activated BV2 cells with an IC₅₀ value of 22.41 μM.

Key words: Aglaia odorata Lour., Diterpenoids, Triterpenoids, Anti-neuroinflammation, Anti-ferroptosis, Neuroprotective activity

Meng Ding, Yue-Han Wang, Chen-Hao Liu, Wang-Xiao Tan, Li-Ming Hu, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang. Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.[J]. 应用天然产物, 2026, 16(1): 10-10.

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Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

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