Research Progress of the Antiviral Bioactivities of Natural Flavonoids

doi:10.1007/s13659-020-00257-x

应用天然产物 ›› 2020, Vol. 10 ›› Issue (5): 271-283.DOI: 10.1007/s13659-020-00257-x

• REVIEW • 下一篇

Research Progress of the Antiviral Bioactivities of Natural Flavonoids

Lin Wang¹, Junke Song¹, Ailin Liu¹, Bin Xiao², Sha Li¹, Zhang Wen¹, Yang Lu¹, Guanhua Du¹

1 Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China;
2 Laboratory of Clinical Pharmacy, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Ordos 017000, China

收稿日期:2020-05-22 修回日期:2020-06-24 出版日期:2020-10-24 发布日期:2020-10-23
通讯作者: Guanhua Du
基金资助:
The work was supported by CAMS Innovation Fund for Medical Sciences (Grant No. 2017-I2M-1-010); National Key Research and Development Program (Grant No. 2018YFC0311005); National Science and Technology Major Projects (Grant No. 2018ZX09711001-012).

Research Progress of the Antiviral Bioactivities of Natural Flavonoids

Lin Wang¹, Junke Song¹, Ailin Liu¹, Bin Xiao², Sha Li¹, Zhang Wen¹, Yang Lu¹, Guanhua Du¹

1 Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China;
2 Laboratory of Clinical Pharmacy, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Ordos 017000, China

Received:2020-05-22 Revised:2020-06-24 Online:2020-10-24 Published:2020-10-23
Contact: Guanhua Du
Supported by:
The work was supported by CAMS Innovation Fund for Medical Sciences (Grant No. 2017-I2M-1-010); National Key Research and Development Program (Grant No. 2018YFC0311005); National Science and Technology Major Projects (Grant No. 2018ZX09711001-012).

摘要/Abstract

摘要： Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids, highlights the cellular and molecular mechanisms of natural flavonoids on viruses, and presents the details of most reported flavonoids. Meanwhile, future perspectives on therapeutic applications of flavonoids against viral infections were discussed.

关键词: Antiviral bioactivities, Natural flavonoids, Cellular and molecular mechanisms, Therapeutic applications

Abstract: Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids, highlights the cellular and molecular mechanisms of natural flavonoids on viruses, and presents the details of most reported flavonoids. Meanwhile, future perspectives on therapeutic applications of flavonoids against viral infections were discussed.

Key words: Antiviral bioactivities, Natural flavonoids, Cellular and molecular mechanisms, Therapeutic applications

Lin Wang, Junke Song, Ailin Liu, Bin Xiao, Sha Li, Zhang Wen, Yang Lu, Guanhua Du. Research Progress of the Antiviral Bioactivities of Natural Flavonoids[J]. 应用天然产物, 2020, 10(5): 271-283.

Lin Wang, Junke Song, Ailin Liu, Bin Xiao, Sha Li, Zhang Wen, Yang Lu, Guanhua Du. Research Progress of the Antiviral Bioactivities of Natural Flavonoids[J]. Natural Products and Bioprospecting, 2020, 10(5): 271-283.

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Research Progress of the Antiviral Bioactivities of Natural Flavonoids

Research Progress of the Antiviral Bioactivities of Natural Flavonoids

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