Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori

doi:10.1007/s13659-014-0033-3

应用天然产物 ›› 2014, Vol. 4 ›› Issue (4): 227-231.DOI: 10.1007/s13659-014-0033-3

• Original article • 上一篇下一篇

Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori

Tomofumi Miyamoto¹, Tadayoshi Okimoto², Michihiko Kuwano³

1. Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan;
2. Department of Gastroenterology, Oita University Faculty of Medicine, Oita, Japan;
3. Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

收稿日期:2014-06-04 修回日期:2014-07-02 出版日期:2014-08-24 发布日期:2018-02-11
通讯作者: Tomofumi Miyamoto,e-mail:miyamoto@phar.kyushu-u.ac.jp
作者简介:Tadayoshi Okimoto,e-mail:okimoto@oita-u.ac.jp;Michihiko Kuwano,e-mail:kuwano@phar.kyushu-u.ac.jp
基金资助:
We thank Mr. Hideo Minobe(Alliance Co., Ltd, Fukuoka, Japan) for supply us the mastic gum and also fruitful discussion.

Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori

Tomofumi Miyamoto¹, Tadayoshi Okimoto², Michihiko Kuwano³

1. Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan;
2. Department of Gastroenterology, Oita University Faculty of Medicine, Oita, Japan;
3. Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

Received:2014-06-04 Revised:2014-07-02 Online:2014-08-24 Published:2018-02-11
Supported by:
We thank Mr. Hideo Minobe(Alliance Co., Ltd, Fukuoka, Japan) for supply us the mastic gum and also fruitful discussion.

摘要/Abstract

摘要： Mastic gum is derived from the tree named Pistacia lentiscus that is grown only in Island Hios of Greek. Since Mastic was first reported to kill Helicobacter pylori(H. pylori) in 1998, there has been no further study to elucidate which component of mastic specifically shows the antimicrobial activity against H. pylori. In this study, we examined which component of mastic gum was responsible for anti-H. pylori activity. We prepared the essential oil of mastic gum and identified 20 constituents by GC-MS analysis. Ten standard components were assayed for anti-H. pylori activity, and it clarified that α-terpineol and(E)-methyl isoeugenol showed the anti-H. pylori activity against four different H. pylori strains that were established from patients with gastritis, gastric ulcer and gastric cancer. These components could be useful to overcome the drug-resistance H. pylori growth in stomach.

关键词: Mastic gum, Pistacia lentiscus, Anti-Helicobacter pylori, α-terpineol, (E)-methyl isoeugenol

Abstract: Mastic gum is derived from the tree named Pistacia lentiscus that is grown only in Island Hios of Greek. Since Mastic was first reported to kill Helicobacter pylori(H. pylori) in 1998, there has been no further study to elucidate which component of mastic specifically shows the antimicrobial activity against H. pylori. In this study, we examined which component of mastic gum was responsible for anti-H. pylori activity. We prepared the essential oil of mastic gum and identified 20 constituents by GC-MS analysis. Ten standard components were assayed for anti-H. pylori activity, and it clarified that α-terpineol and(E)-methyl isoeugenol showed the anti-H. pylori activity against four different H. pylori strains that were established from patients with gastritis, gastric ulcer and gastric cancer. These components could be useful to overcome the drug-resistance H. pylori growth in stomach.

Key words: Mastic gum, Pistacia lentiscus, Anti-Helicobacter pylori, α-terpineol, (E)-methyl isoeugenol

Tomofumi Miyamoto, Tadayoshi Okimoto, Michihiko Kuwano. Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori[J]. 应用天然产物, 2014, 4(4): 227-231.

参考文献

1. V. Herrera, J. Parsonnet, Clin. Microbiol. Infect. 15, 971-976 (2009)
2. L.E. Wroblewski, R.M. Peek Jr, K.T. Wilson, Clin. Microbiol. Rev. 23, 713-739 (2010)
3. S. Kabir, Helicobacter 14, 159-171 (2009)
4. K. Fukase, M. Kato, S. Kikuchi, K. Inoue, N. Uemura, S. Okamoto, S. Terao, K. Amagai, S. Hayashi, M. Asaka, Lancet 372, 392-397 (2008)
5. H. Suzuki, T. Nishizawa, T. Hibi, Future Microbiol. 5, 639-648 (2010)
6. C. Hernandez-Hernandez Ldel, E.C. Lazcano-Ponce, Y. LópezVidal, G.R. Aguilar-Gutiérrez, Salud. Pública. Méx 51, 447-454 (2009). Suppl 3
7. S.F.H. Zaidi, I. Yoshida, F. Butt, M.A. Yusuf, K. Usmanghani, M. Kadowaki, T. Sugiyama, Biol. Pharm. Bull. 32, 631-636 (2009)
8. F.U. Huwez, D. Thirlwell, A. Cockayne, D.A.A. Ala'Alden, New Eng. J. Med. 339, 1946 (1998)
9. C. Koutsoudaki, M. Krsek, A. Rodger, J. Agri. Food Chem. 53, 7681-7685 (2005)
10. P. Magiatis, E. Melliou, A.K. Skaltsounis, I.B. Chinou, S. Mitaku, Planta Med. 65, 749-752 (1999)
11. L. Lauk, S. Ragusa, A. Rapisadra, S. Franco, V.M. Nicolosi, J. Chemother. 8, 207-209 (1996)
12. S. Paraschos, P. Magiatis, S. Mitakou, K. Petraki, A. Kalliaropoulos, P. Maragkoudakis, A. Mentis, D. Sgouras, A.L. Skaltsounis, Antimicrob. Agents Chemother. 51, 551-559 (2007)
13. N. Uemura, S. Okamoto, S. Yamamoto, N. Matsumura, S. Yamaguchi, M. Yamakido, K. Taniyama, N. Sasaki, R.J. Schlemper, New Eng. J. Med. 345, 784-789 (2001)
14. T. Ohkusa, I. Takashimizu, K. Fujiki, S. Suzuki, K. Shimoi, T. Horiuchi, T. Sakurazawa, K. Ariake, K. Ishii, J. Kumagai, T. Tanizawa, Ann. Intern. Med. 129, 712-715 (1998)
15. M. Stolte, S. Eidt, Lancet 342, 568 (1993)
16. A.C. Wotherspoon, C. Doglioni, T.C. Diss, L. Pan, A. Moschini, M. de Boni, P.G. Isaacson, Lancet 342, 575-577 (1993)
17. E.M. El-Omar, I.D. Penman, J.E.S. Ardill, R.S. Chittajallu, C. Howie, K.E.L. McColl, Gastroenterology 109, 681-691 (1995)
18. Therapeutic guideline for Helicobacter pylori infection 2009. Jpn. J. Helicobacter Res. 10 suppl, 1-25. http://www.jshr.jp/. Accessed 15 March 2009
19. E. Rimbara, N. Noguchi, M. Tanabe, T. Kawai, Y. Matsumoto, S.M. Asatsu, Clin. Microbiol. Infect. 11, 307-311 (2005)

Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori

Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价