Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

doi:10.1007/s13659-017-0148-4

应用天然产物 ›› 2018, Vol. 8 ›› Issue (1): 47-56.DOI: 10.1007/s13659-017-0148-4

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

收稿日期:2017-10-31 修回日期:2017-12-04 出版日期:2018-02-24 发布日期:2018-02-27
基金资助:
We gratefully acknowledge financial support from the independent topics supported by operational expenses for basic research of China Academy of Chinese Medical Sciences (ZXKT15032).

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2017-10-31 Revised:2017-12-04 Online:2018-02-24 Published:2018-02-27
Contact: An Liu

摘要/Abstract

摘要： Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC₅₀ values ranging from 7.1 to 31.3 μM.

关键词: Aesculus chinensis, Triterpenoid saponins, Chemical structures, Anti-tumor activity

Abstract: Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC₅₀ values ranging from 7.1 to 31.3 μM.

Key words: Aesculus chinensis, Triterpenoid saponins, Chemical structures, Anti-tumor activity

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu. Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities[J]. 应用天然产物, 2018, 8(1): 47-56.

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Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

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