Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla

doi:10.1007/s13659-016-0102-x

应用天然产物 ›› 2016, Vol. 6 ›› Issue (4): 205-210.DOI: 10.1007/s13659-016-0102-x

• Original article • 上一篇下一篇

Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla

Ling-Yu Jin^1,2, Ting-Xiang Lu²², . Xu-Jie Qin², Wei Ni², Huan Yan³, Yu Chen³, Hui Liu¹, Hong-Ping He²

1. College of Pharmacy and Chemistry, Dali University, Dali 671000, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2016-04-15 修回日期:2016-05-13 出版日期:2016-08-24 发布日期:2018-02-08
通讯作者: Hong-Ping He,e-mail:95431111@qq.com;Hai-Yang Liu,e-mail:haiyangliu@mail.kib.ac.cn
基金资助:
This work is funded by the National Natural Science Funding of China (Grand No.31570363);the Key Research Program of the Chinese Academy of Sciences (Grand No.KSZDEW-Z-004-03-4),and the Natural Science Foundation of Yunnan Province (Grand No.2015FA031)

Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla

Ling-Yu Jin^1,2, Ting-Xiang Lu²², . Xu-Jie Qin², Wei Ni², Huan Yan³, Yu Chen³, Hui Liu¹, Hong-Ping He²

1. College of Pharmacy and Chemistry, Dali University, Dali 671000, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2016-04-15 Revised:2016-05-13 Online:2016-08-24 Published:2018-02-08
Supported by:
This work is funded by the National Natural Science Funding of China (Grand No.31570363);the Key Research Program of the Chinese Academy of Sciences (Grand No.KSZDEW-Z-004-03-4),and the Natural Science Foundation of Yunnan Province (Grand No.2015FA031)

摘要/Abstract

摘要： Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A (1) and B (2), together with seven known compounds. Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry, as well as chemical methods. In addition, the cytotoxicity of the two new saponins was tested.

关键词: Paris polyphylla var. stenophylla, Liliaceae, Spirostanol saponins, Paristenoside A, Paristenoside B

Abstract: Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A (1) and B (2), together with seven known compounds. Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry, as well as chemical methods. In addition, the cytotoxicity of the two new saponins was tested.

Key words: Paris polyphylla var. stenophylla, Liliaceae, Spirostanol saponins, Paristenoside A, Paristenoside B

Ling-Yu Jin, Ting-Xiang Lu,. Xu-Jie Qin, Wei Ni, Huan Yan, Yu Chen, Hui Liu, Hong-Ping He, Hai-Yang Liu. Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla[J]. 应用天然产物, 2016, 6(4): 205-210.

参考文献

1. H. Li, The Genus Paris (Science Press, Beijing, 1998), pp. 12-16
2. Chinese Pharmacopoeia Commission, Pharmacopoeia of the People's Republic of China, vol. 1 (Chinese Medical Science and Technology Press, Beijing, 2015), pp. 243-244
3. Z.X. Cheng, B.R. Liu, X.P. Qian, Y.T. Ding, W.J. Hu, J. Sun, L.X. Yu, J. Ethnopharmacol. 120, 129-137 (2008)
4. S.L. Man, W.Y. Gao, Y.J. Zhang, L.L. Yan, C.Y. Ma, C.X. Liu, L.Q. Huang, Steroids 74, 1051-1056 (2009)
5. Y.L. Fu, Z.Y. Yu, X.M. Tang, Y. Zhao, X.L. Yuan, S. Wang, B.P. Ma, Y.W. Cong, J. Thromb. Haemost. 6, 524-533 (2007)
6. D.W. Deng, D.R. Lauren, J.M. Cooney, D.J. Jensen, K.V. Wurms, J.E. Upritchard, R.D. Cannon, M.Z. Wang, M.Z. Li, Planta Med. 74, 1397-1402 (2008)
7. X.J. Qin, D.J. Sun, W. Ni, C.X. Chen, Y. Hua, L. He, H.Y. Liu, Steroids 77, 1242-1248 (2012)
8. X.J. Qin, C.X. Chen, W. Ni, H. Yan, H.Y. Liu, Fitoterapia 84, 248-251 (2013)
9. C.L. Sun, W. Ni, H. Yan, Z.H. Liu, L. Yang, Y.A. Si, Y. Hua, C.X. Chen, L. He, J.H. Zhao, H.Y. Liu, Steroids 92, 90-95 (2014)
10. Y.S. Wen, W. Ni, X.J. Qin, H. Yan, C.X. Chen, Y. Hua, Y.C. Cheng, L. He, H.Y. Liu, Phytochem. Lett. 12, 31-34 (2015)
11. X.J. Qin, M.Y. Yu, W. Ni, H. Yan, C.X. Chen, Y.C. Cheng, L. He, H.Y. Liu, Phytochemistry 121, 20-29 (2016)
12. H.X. Yin, F.Y. Wen, H. Zhang, World Sci Technol. Mod. Trad. Chin. Med. Mat. Med. 16, 177-180 (2014)
13. H.X. Yin, D. Xue, N. Bai, C. Chen, Y. Chen, H. Zhang, J. Sichuan Univ. (Med. Sci. Edi.) 39, 485-488 (2008)
14. C.X. Chen, J. Zhou, Y.T. Zhang, C.K. Gao, Acta Bot. Yunnan. 5, 219-223 (1983)
15. C.X. Chen, Y.T. Zhang, J. Zhou, Acta Bot. Yunnan. 5, 91-97 (1983)
16. C.X. Chen, J. Zhou, Acta Bot. Yunnan. 3, 89-93 (1981)
17. T. Nohara, K. Migahara, T. Kawasaki, Chem. Pharm. Bull. 23, 872-885 (1975)
18. K. Nakano, K. Murakami, T. Nohara, T. Tomimatsu, T. Kawasaki, Chem. Pharm. Bull. 29, 1445-1451 (1981)
19. C.M. Xiao, J. Huang, X.M. Zhong, X.Y. Tan, P.C. Deng, Helv. Chim. Acta 92, 2587-2595 (2009)
20. T. Zhang, H. Liu, X.T. Liu, X.Q. Chen, Q. Wang, Steroids 74, 809-813 (2009)
21. R. Kasai, M. Okihara, J. Asakawa, K. Mizutani, O. Tanaka, Tetrahedron 35, 1427-1432 (1979)
22. L.P. Kang, Y.X. Liu, T. Eichhorn, E. Dapat, H.S. Yu, Y. Zhao, C.Q. Xiong, C. Liu, T. Efferth, B.P. Ma, J. Nat. Prod. 75, 1201-1205 (2012)

[1]	Mei-Ling Xiang, Bin-Yuan Hu, Zi-Heng Qi, Xiao-Na Wang, Tian-Zhen Xie, Zhao-Jie Wang, Dan-Yu Ma, Qi Zeng, Xiao-Dong Luo. Chemistry and bioactivities of natural steroidal alkaloids[J]. 应用天然产物, 2022, 12(4): 23-23.
[2]	Wen-Tao Gao, Ling-Ling Yu, Jing Xie, Long-Gao Xiao, Shi-Juan Zhang, Wen-Yi Ma, Huan Yan, Hai-Yang Liu. Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica[J]. 应用天然产物, 2022, 12(3): 17-17.
[3]	Yu Chen, Yong-Ai Si, Wei Ni, Huan Yan, Xu-Jie Qin, Chang-Xiang Chen, Hai-Yang Liu. Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis[J]. 应用天然产物, 2016, 6(3): 173-182.
[4]	Yong-Ai Si, Huan Yan, Wei Ni, Zhen-Hua Liu, Ting-Xiang Lu, Chang-Xiang Cheng, Hai-Yang Liu. Two New Steroidal Saponins from Ypsilandra thibetica[J]. 应用天然产物, 2014, 4(6): 315-318.
[5]	Hai-Yang LIU, Chang-Xiang CHEN, Yi LU, Jun-Yun YANG, Wei NI. Steroidal and pregnane glycosides from Ypsilandra thibetica[J]. 应用天然产物, 2012, 2(1): 11-15.

Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla

Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 5

编辑推荐

Metrics

本文评价