Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis

doi:10.1007/s13659-016-0098-2

应用天然产物 ›› 2016, Vol. 6 ›› Issue (3): 173-182.DOI: 10.1007/s13659-016-0098-2

• Original article • 上一篇下一篇

Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis

Yu Chen^1,2, Yong-Ai Si^1,2, Wei Ni¹, Huan Yan¹, Xu-Jie Qin¹, Chang-Xiang Chen¹, Hai-Yang Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China

收稿日期:2016-03-15 修回日期:2016-04-07 出版日期:2016-06-24 发布日期:2018-02-08
通讯作者: Hai-Yang Liu,e-mail:haiyangliu@mail.kib.ac.cn
基金资助:
This work was supported by the National Natural Science Funding of China (Grants 31170333 and 31570363)

Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis

Yu Chen^1,2, Yong-Ai Si^1,2, Wei Ni¹, Huan Yan¹, Xu-Jie Qin¹, Chang-Xiang Chen¹, Hai-Yang Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China

Received:2016-03-15 Revised:2016-04-07 Online:2016-06-24 Published:2018-02-08
Supported by:
This work was supported by the National Natural Science Funding of China (Grants 31170333 and 31570363)

摘要/Abstract

摘要： Phytochemicalinvestigationonthewholeplantsof Ypsilandrayunnanensiswascarriedoutforthefirsttimeandledtothe isolation of five new cholestanol glycosides, ypsiyunnosides A-E (1-5), and one known analogue. Their structures were determined mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS and UV, as well as chemical methods. Among them, compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon, which was identified as (23R,25R)-3β,16α,26-triol- 16,23-cyclocholest-5,17(20)-dien-22-one. Their induced platelet aggregation activities and cytotoxicities were evaluated.

关键词: Ypsilandra yunnanensis, Liliaceae, Cholestane glycoside, Ypsiyunnosides A-E

Abstract: Phytochemicalinvestigationonthewholeplantsof Ypsilandrayunnanensiswascarriedoutforthefirsttimeandledtothe isolation of five new cholestanol glycosides, ypsiyunnosides A-E (1-5), and one known analogue. Their structures were determined mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS and UV, as well as chemical methods. Among them, compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon, which was identified as (23R,25R)-3β,16α,26-triol- 16,23-cyclocholest-5,17(20)-dien-22-one. Their induced platelet aggregation activities and cytotoxicities were evaluated.

Key words: Ypsilandra yunnanensis, Liliaceae, Cholestane glycoside, Ypsiyunnosides A-E

Yu Chen, Yong-Ai Si, Wei Ni, Huan Yan, Xu-Jie Qin, Chang-Xiang Chen, Hai-Yang Liu. Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis[J]. 应用天然产物, 2016, 6(3): 173-182.

Yu Chen, Yong-Ai Si, Wei Ni, Huan Yan, Xu-Jie Qin, Chang-Xiang Chen, Hai-Yang Liu. Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis[J]. Natural Products and Bioprospecting, 2016, 6(3): 173-182.

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Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis

Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis

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