Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

doi:10.1007/s13659-011-0045-1

应用天然产物 ›› 2011, Vol. 1 ›› Issue (3): 129-133.DOI: 10.1007/s13659-011-0045-1

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Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

Zhi-Qiang PAN, Ji-Xuan LIANG, Jing-Bo CHEN, Xiao-Dong YANG, Hong-Bin ZHANG

Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China

收稿日期:2011-12-09 修回日期:2011-12-19 出版日期:2011-06-24 发布日期:2018-02-11
通讯作者: Xiao-Dong YANG,E-mail:zhanghb@ynu.edu.cn;Hong-Bin ZHANG,E-mail:xdyang@ynu.edu.cn
基金资助:
This work was supported by grants(20925205, 21062026, 2010GA014 and 2009CB522300) from National Natural Science Foundation of China, Yunnan Province and National Basic Research Program of China(973 Program).

Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

Zhi-Qiang PAN, Ji-Xuan LIANG, Jing-Bo CHEN, Xiao-Dong YANG, Hong-Bin ZHANG

Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China

Received:2011-12-09 Revised:2011-12-19 Online:2011-06-24 Published:2018-02-11
Supported by:
This work was supported by grants(20925205, 21062026, 2010GA014 and 2009CB522300) from National Natural Science Foundation of China, Yunnan Province and National Basic Research Program of China(973 Program).

摘要/Abstract

摘要： A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed. The key process is an oxidative carbon-carbon coupling followed by a conjugated addition. Based on this new strategy, a formal synthesis of demethoxyerythratidinone was completed in only 6 steps from 4-aminophenol.

关键词: erythrina alkaloid, oxidative dearomation, demethoxyerythratidinone, formal synthesis

Abstract: A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed. The key process is an oxidative carbon-carbon coupling followed by a conjugated addition. Based on this new strategy, a formal synthesis of demethoxyerythratidinone was completed in only 6 steps from 4-aminophenol.

Key words: erythrina alkaloid, oxidative dearomation, demethoxyerythratidinone, formal synthesis

Zhi-Qiang PAN, Ji-Xuan LIANG, Jing-Bo CHEN, Xiao-Dong YANG, Hong-Bin ZHANG. Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone[J]. 应用天然产物, 2011, 1(3): 129-133.

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Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

Oxidative dearomatic approach towards the synthesis of erythrina skeleton: a formal synthesis of demethoxyerythratidinone

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