Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride

doi:10.1007/s13659-019-0200-7

应用天然产物 ›› 2019, Vol. 9 ›› Issue (2): 149-155.DOI: 10.1007/s13659-019-0200-7

• ORIGINAL ARTICLE • 上一篇下一篇

Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride

Li-Xia Wang^1,2, Xian-Jun Jiang^1,2, Xiang-Mei Li^1,2, Mei-Fen Mao^1,2, Guo-Zhu Wei^1,2, Fei Wang^1,2

1 BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2 Reference Substances Sub-center, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China

收稿日期:2019-01-15 修回日期:2019-02-21 出版日期:2019-04-24 发布日期:2019-04-04
通讯作者: Fei Wang
基金资助:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride

Li-Xia Wang^1,2, Xian-Jun Jiang^1,2, Xiang-Mei Li^1,2, Mei-Fen Mao^1,2, Guo-Zhu Wei^1,2, Fei Wang^1,2

1 BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2 Reference Substances Sub-center, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China

Received:2019-01-15 Revised:2019-02-21 Online:2019-04-24 Published:2019-04-04
Contact: Fei Wang
Supported by:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

摘要/Abstract

摘要： Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid (1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone (2),9-epidebilon (3),and one rare aristolane-chalcone hybrid,namely 3'-hydroxynardoaristolone A (4) were isolated from the ethanol extract of the roots and rhizomes of Nardostachys chinensis.Their structures were elucidated on the basis of extensive spectroscopic analysis.In addition,the structure of aristolanhydride,recently isolated from the same species,was corrected by reanalysis of the published NMR data.

关键词: Nardostachys chinensis, Aristolane, Secoaristolane, Aristolane-chalcone hybrid, Structural revision

Abstract: Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid (1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone (2),9-epidebilon (3),and one rare aristolane-chalcone hybrid,namely 3'-hydroxynardoaristolone A (4) were isolated from the ethanol extract of the roots and rhizomes of Nardostachys chinensis.Their structures were elucidated on the basis of extensive spectroscopic analysis.In addition,the structure of aristolanhydride,recently isolated from the same species,was corrected by reanalysis of the published NMR data.

Key words: Nardostachys chinensis, Aristolane, Secoaristolane, Aristolane-chalcone hybrid, Structural revision

Li-Xia Wang, Xian-Jun Jiang, Xiang-Mei Li, Mei-Fen Mao, Guo-Zhu Wei, Fei Wang. Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride[J]. 应用天然产物, 2019, 9(2): 149-155.

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Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride

Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride

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