Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

doi:10.1007/s13659-019-0197-y

应用天然产物 ›› 2019, Vol. 9 ›› Issue (2): 139-144.DOI: 10.1007/s13659-019-0197-y

• ORIGINAL ARTICLE • 上一篇下一篇

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Chang-An Geng^1,2, Meng-Hong Yan^1,2, Xue-Mei Zhang^1,2, Ji-Jun Chen^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Kunming 650201, Yunnan, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

收稿日期:2018-11-26 修回日期:2019-01-06 出版日期:2019-04-24 发布日期:2019-04-04
通讯作者: Ji-Jun Chen
基金资助:
This work was financially supported by the Program of Yunling Scholarship,the CAS "Light of West China" Program (Western Youth Scholars "A"),the Youth Innovation Promotion Association CAS (2013252),and the Applied Basic Research Programs of Yunnan Province (2017FB137).

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Chang-An Geng^1,2, Meng-Hong Yan^1,2, Xue-Mei Zhang^1,2, Ji-Jun Chen^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Kunming 650201, Yunnan, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2018-11-26 Revised:2019-01-06 Online:2019-04-24 Published:2019-04-04
Contact: Ji-Jun Chen
Supported by:
This work was financially supported by the Program of Yunling Scholarship,the CAS "Light of West China" Program (Western Youth Scholars "A"),the Youth Innovation Promotion Association CAS (2013252),and the Applied Basic Research Programs of Yunnan Province (2017FB137).

摘要/Abstract

摘要： A new flavane,bropapyriferol (1),and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay.The structure of compound 1 was determined by extensive 1D and 2D NMR,[α]_D spectroscopic data and quantum computation.Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro.Especially,compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis(MIC=1.95 ppm) than the positive control,triclosan.

关键词: Bropapyriferol, Broussonetia papyrifera, Anti-oral microbial activity

Abstract: A new flavane,bropapyriferol (1),and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay.The structure of compound 1 was determined by extensive 1D and 2D NMR,[α]_D spectroscopic data and quantum computation.Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro.Especially,compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis(MIC=1.95 ppm) than the positive control,triclosan.

Key words: Bropapyriferol, Broussonetia papyrifera, Anti-oral microbial activity

Chang-An Geng, Meng-Hong Yan, Xue-Mei Zhang, Ji-Jun Chen. Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay[J]. 应用天然产物, 2019, 9(2): 139-144.

Chang-An Geng, Meng-Hong Yan, Xue-Mei Zhang, Ji-Jun Chen. Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay[J]. Natural Products and Bioprospecting, 2019, 9(2): 139-144.

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Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

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