Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

doi:10.1007/s13659-020-00241-5

应用天然产物 ›› 2020, Vol. 10 ›› Issue (3): 153-161.DOI: 10.1007/s13659-020-00241-5

• ORIGINAL ARTICLES • 上一篇下一篇

Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

Ya Gao^1,2, Jian-Chao Chen¹, Xing-Rong Peng¹, Zhong-Rong Li¹, Hai-Guo Su^1,2, Ming-Hua Qiu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

收稿日期:2020-02-28 修回日期:2020-04-17 出版日期:2020-06-24 发布日期:2020-06-02
通讯作者: Ming-Hua Qiu
基金资助:
The work was supported by a program of the National Natural Science Foundation of China (Nos. 31872675 and 81373288) and the cooperation program between Chinese Academy of Sciences and Guangdong Province (2013B09110011).

Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

Ya Gao^1,2, Jian-Chao Chen¹, Xing-Rong Peng¹, Zhong-Rong Li¹, Hai-Guo Su^1,2, Ming-Hua Qiu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

Received:2020-02-28 Revised:2020-04-17 Online:2020-06-24 Published:2020-06-02
Contact: Ming-Hua Qiu
Supported by:
The work was supported by a program of the National Natural Science Foundation of China (Nos. 31872675 and 81373288) and the cooperation program between Chinese Academy of Sciences and Guangdong Province (2013B09110011).

摘要/Abstract

摘要： Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against α-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC₅₀ 87.65±6.51 μM).

关键词: Momordica charantia, Cucurbitane-type triterpene glycosides, α-Glucosidase inhibitory activity

Abstract: Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against α-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC₅₀ 87.65±6.51 μM).

Key words: Momordica charantia, Cucurbitane-type triterpene glycosides, α-Glucosidase inhibitory activity

Ya Gao, Jian-Chao Chen, Xing-Rong Peng, Zhong-Rong Li, Hai-Guo Su, Ming-Hua Qiu. Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities[J]. 应用天然产物, 2020, 10(3): 153-161.

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Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

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