Abstract: Four triterpenoid saponins, mimengosides A and B and buddlejasaponins I and Ia were isolated from a traditional Tibetan medicinal plant, Oreosolen wattii Hook. f., together with acteoside and 6-hydroxyluteolin-7-O-glucoside. The in vitro spermicidal activities of the four saponins were tested by a modified Sander-Cramer method. Mimengoside A and buddlejasaponin I Showed stronger activity than the positive control NP-9.

Key words: Oreosolen wattii

摘要： 从藏药植物藏玄参（Oreosolen wattii Hook. f.）的全草中分离到 4个三萜皂甙，密蒙花甙（mimengoside）A和 B及醉鱼草甙（buddlejasaponin）I和 Ia，另外还得到阿克甙（acteoside）和6-羟基木犀草素-7-O-葡萄糖甙（6－hydroxyluteolin-7-O-glucoside）。体外抑精实验表明，4个三萜皂甙均有较强的抑精活性，其中密蒙花甙A和醉鱼草甙I的活性高于阳性对照壬苯醇醚（NP-9）。

关键词: 藏玄参, 支参科, 三萜皂甙, 抑精活性