Abstract: ex LH-20 and preparative RP-HPLC methods. The structures of the isolated lignans were determined on the basis of analyses of spectroscopic methods(¹H- and ¹³C-NMR spectroscopy), high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), and comparison of their spectroscopic data with previously reported data. The lignans were identified as 7″,8″-threo-buddlenol D(1), buddlenol D(2), 7″,8″-threo-buddlenol C(3), buddlenol C(4),(+)-syringaresinol(5), epipinoresinol(6), pinoresinol(7), 1-acetoxyl-2e,6e-dipiperonyl-3,7-dioxabicyclo-[3,3,0]-octane(8), ciwujiatone(9), lariciresinol-4'-O-β-D-glucopyranoside(10), rel-(2α,3β)-7-O-methylcedrusin(11), and dihydrodehydrodiconiferyl-alcohol 4'-O-β-D-glucoside(12). All compounds were isolated from M. paxii for the first time. Some lignans have good pharmacological activities such as antibacterial, anti-inflammatory, anti-tumor and anti-virus. The results of this study show that the leaves of M. paxii are rich in lignans with good activity, indicating that its good medicinal value may be related to these lignans.

Key words: Mallotus, Mallotus paxii ,(+)-syringaresinol, ciwujiatone, pinoresinol

摘要： 为探究红叶野桐(Mallotus paxii )叶的化学成分,该研究采用正相硅胶、反相硅胶C₁₈、葡聚糖凝胶Sephadex LH-20、反相半备高效液相等色谱方法对红叶野桐叶提取物进行分离、纯化,利用¹H-NMR、¹³C-NMR、HR-ESI-MS等波谱数据,结合 参考文献,鉴定化合物的结构。结果表明:从红叶野桐叶中分离得到12个木脂素类化合物,分别是7″,8″-threo-buddlenol D(1)、buddlenol D(2)、7″,8″-threo-buddlenol C(3)、buddlenol C(4)、(+)-丁香脂素(5)、表松脂醇(6)、松脂素(7)、1-acetoxyl-2e,6e-dipiperonyl-3,7-dioxabicyclo-[3,3,0]-octane(8)、刺五加酮(9)、落叶松脂醇-4'-O-β-D-吡喃葡萄糖苷(10)、rel-(2α,3β)-7-O-methylcedrusin(11)和dihydrodehydrodiconiferyl-alcohol 4'-O-β-D-glucoside(12)。以上木脂素类化合物均为首次从该植物中分离得到,部分木脂素类化合物具有良好的药理活性如抗菌、抗肿瘤、抗病毒等。该研究结果表明,红叶野桐叶中含有丰富且活性良好的木脂素类化合物,说明其良好的药用价值可能与这些木脂素类化合物有关。

关键词: 野桐属, 红叶野桐,(+)-丁香脂素, 刺五加酮, 松脂素