Abstract: Eight phenolic constotuents including three specific 5-lipoxidase inhibitors 3-(4-acetoxyphenyl)1-,2,4,7,8-pentacetoxy-dibenaofuran (1), 3-(4-acetoxyphenyl)-7,8-dihydroxy-1,2,4,_triacetoxy-dibenzofuran (2),1,2-diaceroxy-3-(4-hydroxyphanyl)-4.7,8-trihydroxy-divenzofuran (3),and 2,3-diacetoxy-4′,4″,5,6-tetrahydroxy-p-terpheny (4),l,4-benzenediol (5),4-hydroxy-benzoic acid (6),P-anisic acid (7),4-hydroxybevenzaldehyde (8),together with thioacetic anhydride (9) and l-0-β-D-glucopyranosyl-(2s,3R,4E,8E,2′R)-2-N-(2′-hydroxyphenyl)-9-methyl-4,8-sph-ingadienine (10) were isolated from the fruiting bodies of Basidiomycetes Boletopsis grisea (peck) Bond. & Singer (polyporaceae).Their structure were elucidated by spectroscopic evidence.

Key words: Basidiomycetes

摘要： 从担子菌灰黑拟牛肝菌(Boletopsis grisea)新鲜子实体的乙醇提取物中首次分离得到10个化合物,包括8个酚性成分,1个含硫成分和1个脑苷脂,它们的结构经各种波谱数据分别鉴定为3-(4-乙酰氧基苯)-1,2,4,7,8-五乙酰氧基二苯并呋喃(1),3-(4-乙酰氧基苯)-1,2,4-三乙酰氧基-7,8-二羟基二苯并呋喃(2),3-(4-羟基苯)-1,2-二乙酰氧基-4,7,8-三羟基二苯并呋喃(3),2,3-二乙酰氧基-4′,4″, 5,6-四羟基对联三苯(4),对苯二酚(5),对羟基苯甲酸(6),茴香酸(7),对羟基苯甲醛(8),硫代乙酐(9)和1-O-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基棕榈酰)-9-甲基-4,8-sphingadienine(10).其中化合物1,2,3有报道对5-脂氧化酶具有选择性抑制活性.4,9,10均为首次从该属真菌中分离得到.

关键词: 担子菌, 灰黑拟牛肝菌, 化学成分