Abstract: In this paper the isolation and the structure elucidation of tow new diter- pene lactones, hypolide C20H24o3 (1) and tripterolide C20H24o7(V) are repoted. Hypolide was iso1ated from T. hypoglucum (Levl) Hutch. with yield 0.0005%, and from T. regelii Spzagus et Takeda, T. forestii Dicls, T. wilfordii Hook. The elementa1 analysis, UV, IR, MS, NMR spectra data and derivatives of methylation, hydrogenation have indicated it to be diterpene α,β-unsaturated-γ-lactone, and no peresence of epoxide groups, ring-C to be a substittuted arom-atic ring. After methylation with dimethyl sulfate, the ring-C similar to the intermediate product (Ⅶ) of the total synthesis of triptolide.

Key words: Diterpen lactones

摘要： 本文报告了从昆明山海棠根皮中分离得两个新二萜内酯山棠素（I）和雷藤素丙 （V)。山海棠素是雷公藤属四个种共有的化学成分。雷藤素丙从昆明山海棠分离得，其紫外光谱、红外光谱、质谱、核磁共振谱的数据与雷藤素甲、雷藤素乙和雷藤酮相比较，推测雷藤素丙是2-α-OH雷藤素乙。山海棠素可能是雷藤素类化合物生物合成的前体之一。

关键词: 雷公藤属, 二萜内酯, 山海棠素, 雷藤素内